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June 06.2025
3 Minutes Read

Nefecon's Groundbreaking Efficacy in IgAN: A Potential Game-Changer for All eGFR Levels

Kidney models wrapped in tape, symbolizing Nefecon IgAN benefits.

Understanding IgAN and the Role of Nefecon in Treatment

Immunoglobulin A nephropathy (IgAN) is a kidney disease characterized by the deposition of IgA antibodies, leading to inflammation and damage over time. As its prevalence rises, innovations in treatment are critical. Nefecon, a novel oral formulation of budesonide, is specifically designed to release the medication in the distal ileum, targeting the underlying causes of IgAN. Recent findings from the NeflgArd study shed light on its efficacy, particularly concerning patients' baseline kidney function, measured by estimated glomerular filtration rate (eGFR).

Key Insights from the NeflgArd Study

The NeflgArd study, which involved over 360 patients with primary IgAN, revealed significant improvements in kidney function with Nefecon over a nine-month treatment period, regardless of baseline eGFR levels. This is groundbreaking because it suggests that physicians can reliably prescribe Nefecon to IgAN patients across the spectrum of kidney function without adjusting treatment based on eGFR benchmarks.

Researchers stratified patients based on their eGFR deciles, noting consistently favorable outcomes across the board, particularly in those with higher eGFR above 72 mL/min/1.73 m². This data underscores a progressive understanding of how targeted therapies can mitigate the ramifications of chronic kidney diseases.

The Importance of Early Intervention and Continuous Monitoring

In chronic diseases like IgAN, early intervention is key to managing health outcomes effectively. The results from this study emphasize a proactive approach. With Nefecon showing a pronounced ability to delay the decline of kidney function for up to two years, patients and healthcare providers alike must prioritize timely diagnosis and treatment to leverage these benefits.

Moreover, continuous monitoring of kidney function, including eGFR and proteinuria levels, allows for tailored patient care strategies, increasing the chances of better health outcomes. This aligns with current healthcare trends emphasizing preventive care and personalized medicine.

Engaging Healthcare Innovations for Better Patient Care

As the healthcare landscape evolves, innovative solutions like digital health technologies and telemedicine are enhancing patient care. AI-driven healthcare solutions are leading to smarter patient monitoring, enabling healthcare providers to act swiftly based on real-time data.

For patients managing chronic conditions like IgAN, remote patient monitoring technology ensures that they can keep their healthcare providers informed easily, ensuring that care is not only effective but also convenient. The integration of such technologies emphasizes the shift toward more personalized healthcare solutions that empower patients in their treatment journeys.

Future Directions and Conclusion

The findings support a broader application of Nefecon in treating IgAN and highlight the need for continued research into its long-term effects. As healthcare progresses, innovations such as Nefecon pave the way for more effective interventions, improving the quality of life for patients battling chronic conditions.

Patients and caregivers should remain informed about emerging treatment options, as knowledge is empowerment. As healthcare continues to advance, leveraging tools like telemedicine, and embracing innovation will be crucial in managing health and wellness strategically. Together, we can foster an environment where ongoing support and informed decisions lead to better patient outcomes.

Take Action: Stay Informed on Treatment Options

Stay abreast of the latest developments in patient care. Awareness of revolutionary treatments like Nefecon could be vital for those affected by IgAN, encouraging timely discussions with healthcare providers about treatment strategies that encompass their unique health needs.

Better Patient Care

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06.08.2025

Exploring Limited Survival Benefit of Expanded Kidney Donor Criteria: What Patients Should Know

Update Understanding Expanded Criteria for Kidney Donors The landscape of kidney transplantation is evolving, especially as the need for viable donor organs continues to outpace supply. The recent study presented at the 62nd European Renal Association Congress in 2025 offers critical insights into the use of expanded-criteria donors (ECD). These donors are often older or present with comorbidities that could compromise transplant success. However, for many patients, the prospect of receiving a transplant—even from an ECD—may provide an opportunity they would not have otherwise due to the diminishing number of standard-criteria donors. The Split Decision: Quality Versus Quantity in Transplants Following Dr. Rachel Hellemans’ presentation, it becomes evident that while ECDs offer a solution to the donor shortage, the survival benefit for recipients may not compare favorably to that achieved with standard donors. As Hellemans noted, ''While transplanting can lead to significantly improved health outcomes versus prolonged dialysis, the quality of the kidney matters. A deeper understanding is essential when determining candidates for transplantation.'' This brings up the dilemma that often faces both patients and clinicians: the urgency for a transplant versus the inherent risks associated with suboptimal donor matches. Navigating the Risks of ECDs Potential kidney transplant recipients must carefully weigh the immediate benefits against possible complications. Expanded-criteria donation can lead to poorer long-term outcomes, raising questions about how quickly patients should settle for an ECD kidney. As noted by Hellemans, ''There remains some unpredictable risk during the early post-transplant period.'' Patients must ensure clear communication with their healthcare providers about these risks while remaining hopeful about the transplantation's potential to enhance their quality of life in the short term, even if they ultimately face more challenges ahead. Alterations in Patient Expectations and Outcomes Understanding the intricacies of kidney transplantation also means to recognize the evolving patient expectations. Patients on dialysis are experiencing improved survival rates, altering the perspective on how urgent a transplant may need to be. With advances in dialysis treatment, individuals are now living longer, potentially leading them to take additional time to find an ideal kidney, rather than just accepting any available organ. Clarity Through Data: A Look at the ERA Registry The findings from the ERA Registry examine over 64,000 individuals, emphasizing the validity of data-driven decisions in healthcare. But Hellemans' caution regarding the biases that can skew results stands as a poignant reminder for the medical community. Rigorous pre-transplant assessments are crucial, but it’s just as important to understand that no two patients’ outcomes can be predicted with certainty. The Future of Kidney Transplants: Ethical Considerations As medicine advances, the ethical implications of using ECDs in transplantation will remain a pressing topic. Can we ethically justify the use of kidneys from older donors or those with health conditions for patients who may experience shortened lifespan post-transplant? The discussions surrounding patient autonomy, informed consent, and overall healthcare policy will only grow in significance as healthcare systems grapple with improving access to transplantation amid limited resources. Take Charge of Your Health Journey For patients and caregivers, the evolving landscape of healthcare and kidney transplants offers actionable insights. Whether it’s understanding the risks associated with ECDs or engaging deeply with healthcare teams to make informed choices about patient care, staying informed is key. As we enhance our knowledge about medical advancements and patient care tips, proactive engagement can lead to better health and wellness outcomes. In summary, while the introduction of expanded criteria donors may alleviate some pressure from the organ shortage, it’s important for patients, families, and healthcare providers to have candid discussions about the associated risks. By analyzing personal health needs and expectations, they can make informed decisions that best serve their futures. Empower yourself with knowledge and resources about chronic disease management, patient well-being strategies, and the latest healthcare innovations to navigate your health journey. Remember, you hold the key to your health!

06.08.2025

Pegcetacoplan Shows Promising Results in Kidney Disease Management After 52 Weeks

Update The Groundbreaking Results of Pegcetacoplan for Kidney Health Recent 52-week results from the VALIANT trial offer hope for patients suffering from C3 glomerulopathy and primary immune complex membranoproliferative glomerulonephritis (IC-MPGN). Pegcetacoplan, a targeted C3/C3b inhibitor, demonstrates sustained improvements in vital kidney health markers, something previously underexplored in conventional treatments. Understanding the VALIANT Trial The VALIANT trial is notable for its comprehensive approach, which involved 124 patients split between a treatment group and a placebo group. Patients received pegcetacoplan injections either systematically or based on their weight (for adolescents). After 26 weeks, participants from the placebo group switched to pegcetacoplan, enabling researchers to track the drug's efficacy over time. Impressive Outcomes from 52 Weeks By week 52, patients initially on pegcetacoplan maintained a remarkable 68.3% reduction in protein levels in the urine, compared to only 3.2% in the placebo group before their transition. More importantly, those who switched from placebo to pegcetacoplan had a significant reduction of 51.3% in their proteinuria levels. These improvements highlight the drug's potential in managing chronic kidney issues and improving patient outcomes significantly. The Importance of Proteinuria Reduction Proteinuria, the presence of excess protein in urine, is a key sign of kidney damage. Reducing proteinuria can substantially slow the progression of kidney disease. Pegcetacoplan's effective reduction can lead to better long-term health for patients, further emphasizing the need for continuous monitoring and patient engagement in managing chronic illnesses. Improved Tolerability Over Time One of the significant findings during the trial was the marked improvement in tolerability of pegcetacoplan treatments over the 52 weeks. Infusion-related treatment-emergent adverse events (TEAEs) decreased significantly, suggesting that adherence to treatment can be improved. This finding is crucial as it encourages patients to remain committed to their healthcare regimens. The Broader Impact of Pegcetacoplan on Patient Care Beyond individual health risks, pegcetacoplan's effects parallel larger trends in healthcare focusing on personalized treatment options. As medical advancements in technologies such as AI in healthcare continue to grow, patients can expect more tailored strategies that ensure better health outcomes. This places greater responsibility on both patients and healthcare providers to stay informed and engaged. Empowering Patients Through Knowledge By staying updated on emerging treatments like pegcetacoplan, patients become empowered in their care journeys. Understanding advancements can inspire confidence in managing chronic diseases, fostering a proactive approach in collaboration with healthcare professionals. The potential of AI-driven healthcare solutions to amplify these benefits cannot be understated. A Call to Action for Optimal Patient Engagement As exemplified in the VALIANT trial, the journey toward better patient care does not stop with treatment. Patients must educate themselves about new therapies while actively discussing options with their healthcare providers. This partnership approach ensures that treatment strategies like pegcetacoplan can seamlessly integrate into personalized healthcare plans, ultimately enhancing patient wellness. In conclusion, the transformative results seen with pegcetacoplan underline the importance of sustained research and patient engagement in the management of kidney diseases. As advancements in medical science continue to evolve, so too do the possibilities for patients seeking better outcomes.

06.07.2025

Sibeprenlimab: A Game-Changer Halving uPCR in IgA Nephropathy Trials

Update Transforming Treatment for IgA Nephropathy with SibeprenlimabIn a groundbreaking development for patients with immunoglobulin A (IgA) nephropathy, researchers have revealed that sibeprenlimab, a new selective immune antibody, significantly reduces the urine protein-to-creatinine ratio (uPCR) by over 50% in participants, according to an interim analysis from the VISIONARY trial. Presented at the 62nd European Renal Association Congress, this promising outcome showcases the potential for improved management of a condition that often leads to end-stage kidney disease (ESKD).Understanding the Hidden Toll of IgA NephropathyWith an estimated incidence of 2.5 cases per 100,000 people annually, IgA nephropathy is often overshadowed by other kidney diseases. Dr. Vlado Perkovic, a prominent figure in the study, pointed out the likelihood that these figures underrepresent the true prevalence of the condition. Most diagnoses occur between the ages of 20 to 40, and without adequate treatment, there is a staggering risk—up to 50% of patients may progress to ESKD within two decades. Understanding this condition and its implications is crucial, as it disrupts the lives of many young adults, leading to severe health challenges.The Promise of Sibeprenlimab: A New Mechanism of ActionSibeprenlimab stands out not only for its efficacy but also for its innovative mechanism of action. As a selective IgG2 antibody, it targets APRIL (a proliferation-inducing ligand), crucial in regulating B-cell activity and implicated in the pathogenesis of IgA nephropathy. Unlike traditional corticosteroids, which can unleash a spectrum of side effects, especially related to infections, the initial safety profile of sibeprenlimab presents a beacon of hope for safer and more effective treatment options.Looking Ahead: The VISIONARY Trial and Its ImpactThe VISIONARY trial is pivotal in the landscape of IgA nephropathy treatment. With over 240 sites across 31 countries involved, this extensive study aims to evaluate sibeprenlimab's long-term effects. As we await full results, the enthusiasm from both patients and healthcare providers is palpable. This trial could reshape current therapeutic strategies, potentially leading to better patient outcomes and a renewed focus on personalized healthcare solutions.Challenges and ConsiderationsWhile the results are promising, it is crucial to remain cautious about the long-term implications of innovative treatments. There is an ongoing need to monitor potential off-target effects and the risk of infections associated with immunotherapies. Understanding the complete safety profile of sibeprenlimab will be vital for healthcare providers when considering it for their patients.Empowering Patients and CaregiversFor health-conscious individuals and caregivers, staying informed about advances like sibeprenlimab is vital. This empowers patients to engage in conversations with their healthcare providers and advocate for timely interventions. Education about emerging treatments fosters an environment where patients can make informed choices and adhere to personalized wellness strategies.Next Steps in Advancing Patient WellnessThe emergence of sibeprenlimab underscores the importance of continued investment in medical advancements that prioritize patient safety and efficacy. As we move further into the era of AI in healthcare, these innovations could lead to tailor-made solutions that enhance quality of life for patients with chronic diseases. With ongoing developments in digital health innovations and telemedicine, the future of healthcare looks bright, promising even more breakthroughs.

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Close","city":"London","state":"Brent","zip":"NW100DF","email":"lorenas@getmilerismarketing.com","tos":"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","privacy":"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